Important Patient Information: GLP-1 Agonists and Contraception

We want to ensure all patients are aware of important information regarding GLP-1 agonist medications (such as Tirzepatide, Semaglutide, and others) and how they may interact with contraceptive methods.

What are GLP-1 Agonists?
GLP-1 agonists, including medications like Mounjaro (Tirzepatide), Ozempic/Wegovy (Semaglutide), and others, are prescribed for managing type 2 diabetes and aiding weight loss. They work by slowing down how quickly food leaves the stomach, among other mechanisms.

Impact on Contraception:

• Tirzepatide Users: If you are using Tirzepatide, it’s essential to use a barrier method (like condoms) alongside your contraceptive pill for four weeks after starting the medication and after any dose increases. Alternatively, you may wish to consider a non-oral form of contraception during treatment.
• Other GLP-1 Agonists: There’s currently no evidence that Semaglutide, Exenatide, Liraglutide, Dulaglutide, or Lixisenatide affect oral contraceptive effectiveness.

What If You Experience Vomiting or Diarrhoea?
GLP-1 agonists can cause vomiting or diarrhoea, which might reduce the effectiveness of the contraceptive pill:

• If you vomit within three hours of taking your pill or have severe diarrhoea lasting over 24 hours, follow guidance for missed pills and consider backup contraception.

Non-Oral Contraceptive Methods:
Contraceptive methods like the coil (IUD), implant, injection, patch, or ring are not affected by GLP-1 agonists. No extra precautions are needed with these methods.

Switching Between GLP-1 Medications:
If you’re switching to Tirzepatide from another GLP-1 agonist, use a barrier method for four weeks post-switch and after any dose changes.

Emergency Contraception:
The effect of GLP-1 agonists on oral emergency contraception is still uncertain. The copper IUD remains the most effective and unaffected option. Always inform your healthcare provider about any GLP-1 agonist use when seeking emergency contraception.

Pregnancy Considerations:
GLP-1 agonists should not be used during pregnancy. If planning a pregnancy or if you become pregnant while on treatment, consult your doctor immediately. Washout periods vary by medication:

• Tirzepatide: 1 month
• Semaglutide: 2 months
• Exenatide: 12 weeks